Researchers in India have reported the development of a new live oral cholera vaccine that promises better protection than the currently available killed (or inactivated) vaccines.
Presently two killed whole-cell vaccines, given orally, are licensed by the WHO. Killed or inactivated vaccines are made from microorganisms that have been killed through physical or chemical processes. The Swedish recombinant B-subunit vaccine ‘Dukoral’, licensed since 1991, is expensive. The other oral killed vaccine ‘Shanchol’, marketed by Hyderabad-based Shantha Biotechnics, is a modified form of ‘mORC-Vax’ developed by a Vietnam-based company using technology transferred by Sweden. These vaccines require two doses for protection. The only licensed oral and live attenuated single-dose vaccine CVD 103-HgR that was used in Indonesia in the 1990s is no longer produced.
Read more at the original post : http://www.natureasia.com/en/nindia/article/10.1038/nindia.2014.100
